![]() Eight-methoxypsoralen (Methoxsalen) was applied topically 20 minutes prior to ultraviolet A (UVA) exposure, and the patients were irradiated with UVA twice a week for 16 weeks. Cyclosporine was given at an initial daily dose of 200 mg for adult and 100 mg for children for periods of up to 16 weeks. We sought to determine whether the combination therapy of cyclosporine and psoralen plus ultraviolet A (PUVA) could be an effective treatment for severe AA.Ī total of 41 patients with severe AA were treated with oral cyclosporine and topical PUVA. Treatment with oral ciclosporin resulted in near complete resolution of the alopecia, but after 5 months without treatment the alopecia did not relapse and spontaneous resolution cannot be ruled out.Īlopecia areata (AA) is believed to be an organ-specific autoimmune disease in which a mononuclear cell infiltrate develops in and around anagen hair follicles. The clinical and histopathological features were consistent with a diagnosis of AAU as defined in humans. To the best of the author's knowledge this is the first documented case of canine AAU. Treatment with oral ciclosporin was associated with hair regrowth but muzzle hair, most eyelashes and whiskers were still lacking after 17 months of therapy. The histopathological and immunohistochemical findings supported a diagnosis of long-standing alopecia areata. There was loss of all body hair including eyelashes and vibrissae. To describe a case of canine alopecia areata universalis and its clinical outcome after 22 months of follow-up.Ī 9-year-old intact male cross-breed hunting dog was presented with generalized and complete noninflammatory alopecia of 12-14 months duration.Ĭlinical examination histopathological and immunohistochemical examination of skin biopsies. When the disease progresses to total alopecia it is defined as alopecia areata universalis (AAU), although this outcome has only been described in humans. Alopecia areata is a T-cell mediated autoimmune disease that occurs in humans and various other mammalian species.
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